Proteomics

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Effect of diabetes on the proteomic profile of serum extracellular vesicles in morbidly obese patients after bariatric surgery

ABSTRACT: Obesity and diabetes are linked to cardiometabolic diseases, however study in this field faces hardships as there are substantial prognostic heterogeneity involved. To profile the molecular mechanisms that contribute to the different responses to bariatric surgery dependent on the presence of diabetes, we sought to identify extracellular vesicular proteomic signatures of obesity with or without diabetes before or after bariatric surgery. In this study, extracellular vesicle proteins in 30 morbidly obese patients with (n = 12) or without (n = 18) diabetes were sampled before or 6 months after bariatric surgery and were compared to those in 37 healthy controls, analyzed by using the SWATH-MS analysis.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

SUBMITTER: Kyunggon Kim  

LAB HEAD: Kyunggon Kim

PROVIDER: PXD040143 | Pride | 2025-10-06

REPOSITORIES: Pride

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Dataset's files

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Action DRS
200302-SCH_Exosome_B01_1_r01.wiff Wiff
200302-SCH_Exosome_B01_1_r01.wiff.scan Wiff
200302-SCH_Exosome_B01_2_r01.wiff Wiff
200302-SCH_Exosome_B01_2_r01.wiff.scan Wiff
200302-SCH_Exosome_B02_1_r01.wiff Wiff
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Publications

Impact of diabetes on proteomic changes in circulating extracellular vesicles in individuals with obesity before and after bariatric surgery.

Lee Haekyung H   Han Jae-A JA   Ahn Hee-Sung HS   Kwon Soon Hyo SH   Kim Kyunggon K   Ryu Seongho S  

International journal of obesity (2005) 20250717 9

<h4>Objectives</h4>Extracellular vesicles (EVs) are implicated in the pathophysiology of obesity and diabetes. This study aimed to analyze the impact of diabetes on EV protein dynamics in patients with obesity before and after bariatric surgery.<h4>Methods</h4>This prospective study assessed the serum EV proteins in 30 patients with obesity, with and without diabetes, and 37 healthy controls using liquid chromatography-tandem mass spectrometry. EV proteins were also analyzed 6 months after baria  ...[more]

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