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DNA mimicking 32mer foldamers interfere with in vitro chromatin assembly in drosophila embryo extract

ABSTRACT: Systematic study of the influence of different concentrations of DNA-mimicking foldamers (32mer) on the chromatin-bound bound proteome using an in vitro chromatin assembly extract

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

SUBMITTER: Axel Imhof

LAB HEAD: Axel Imhof

PROVIDER: PXD040158 | Pride | 2023-09-07

REPOSITORIES: Pride

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DNA mimic foldamers affect chromatin composition and disturb cell cycle progression.

Kleene Vera V Corvaglia Valentina V Chacin Erika E Forne Ignasi I Konrad David B DB Khosravani Pardis P Douat Céline C Kurat Christoph F CF Huc Ivan I Imhof Axel A

Nucleic acids research 20231001 18

The use of synthetic chemicals to selectively interfere with chromatin and the chromatin-bound proteome represents a great opportunity for pharmacological intervention. Recently, synthetic foldamers that mimic the charge surface of double-stranded DNA have been shown to interfere with selected protein-DNA interactions. However, to better understand their pharmacological potential and to improve their specificity and selectivity, the effect of these molecules on complex chromatin needs to be inve ...[more]

PMID: 37650653

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