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HRM Proteomic Profiling Discovery Study on Therapeutic Drug Treated Plasma Samples

ABSTRACT: Reveal global quantitative protein differences between plasma samples from mice treated with klotho protein or control (untreated)

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Plasma

SUBMITTER: Jakob Vowinckel

LAB HEAD: Dena Dubal

PROVIDER: PXD040167 | Pride | 2023-10-24

REPOSITORIES: Pride

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Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice.

Park Cana C Hahn Oliver O Gupta Shweta S Moreno Arturo J AJ Marino Francesca F Kedir Blen B Wang Dan D Villeda Saul A SA Wyss-Coray Tony T Dubal Dena B DB

Nature aging 20230816 9

Platelet factors regulate wound healing and can signal from the blood to the brain<sup>1,2</sup>. However, whether platelet factors modulate cognition, a highly valued and central manifestation of brain function, is unknown. Here we show that systemic platelet factor 4 (PF4) permeates the brain and enhances cognition. We found that, in mice, peripheral administration of klotho, a longevity and cognition-enhancing protein<sup>3-7</sup>, increased the levels of multiple platelet factors in plasma, ...[more]

PMID: 37587231

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