Multiomics approaches in Alexander disease zebrafish model show correlation between GFAP aggregation, altered lipid metabolism and oxidative stress

ABSTRACT: In this work we used our zebrafish model of Alexander Desease (AxD), aiming at unraveling the main pathways involved in AxD pathogenesis performing the first multi-omics analysis on a in vivo model of AxD. The obtained results have been functionally validated and they open the way to further investigation about the involvement of metabolic processes in AxD.

INSTRUMENT(S):

ORGANISM(S): Danio Rerio (zebrafish) (brachydanio Rerio)

TISSUE(S): Embryo, Early Embryonic Cell

DISEASE(S): Alexander Disease

SUBMITTER: Gabriela Coronel Vargas  

LAB HEAD: Tiziana Bachetti

PROVIDER: PXD040214 | Pride | 2025-03-03

REPOSITORIES: Pride