Mitochondrial folate one-carbon metabolism moderates Alzheimer’s disease pathology

ABSTRACT: Familial forms of AD cause a loss of neurons associated with the accumulation of toxic amyloid β peptide (Aβ) and mitochondrial dysfunction. We found that flies over expressing a toxic form of Aβ (Aβ-Arc) exhibit altered components of mitochondrial complex I and one-carbon (1C) metabolism.

INSTRUMENT(S):

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

TISSUE(S): Whole Body

SUBMITTER: Luis Martins  

LAB HEAD: L. Miguel Martins

PROVIDER: PXD040263 | Pride | 2025-05-06

REPOSITORIES: Pride