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Mode-of-Action Studies using PfHsp90-Binding Molecules with Anti-Malarial Activity

ABSTRACT: Two PfHsp90-binding molecules, BX2819 and HS292 that have and do not have (respectively) biological activity against the blood and liver stages of Plasmodium Falciparum, were subjected to a Thermal Proteome Profiling analysis to identify the direct and indirect protein target of these molecules.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Plasmodium Falciparum (isolate 3d7)

TISSUE(S): Liver, Blood

DISEASE(S): Malaria

SUBMITTER: Morgan Bailey

LAB HEAD: Dr. Michael C. Fitzgerald

PROVIDER: PXD040417 | Pride | 2024-01-17

REPOSITORIES: Pride

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