Dataset Information
Genetically modified ID8 cells to study the role of GBP1 in ovarian cancer
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Eclipse, LTQ Orbitrap Elite
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cell Culture
DISEASE(S): Malignant Neoplasm Of Ovary
SUBMITTER: 
Sharon Pitteri
LAB HEAD: Sharon Pitteri
PROVIDER: PXD040444 | Pride | 2024-01-26
REPOSITORIES: Pride
Publications
Guanylate-binding protein 1 modulates proteasomal machinery in ovarian cancer.
iScience 20231024 11
Guanylate-binding protein 1 (GBP1) is known as an interferon-γ-induced GTPase. Here, we used genetically modified ovarian cancer (OC) cells to study the role of GBP1. The data generated show that GBP1 inhibition constrains the clonogenic potential of cancer cells. <i>In vivo</i> studies revealed that GBP1 overexpression in tumors promotes tumor progression and reduces median survival, whereas GBP1 inhibition delayed tumor progression with longer median survival. We employed proteomics-based ther ...[more]