Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: Prerana Wagle
LAB HEAD: Bernhard Schermer
PROVIDER: PXD040448 | Pride | 2024-01-26
REPOSITORIES: Pride
Ester Lioba L Cabrita Inês I Ventzke Michel M Kieckhöfer Emilia E Christodoulou Marita M Mandel Amrei M AM Diefenhardt Paul P Fabretti Francesca F Benzing Thomas T Habbig Sandra S Schermer Bernhard B
Human molecular genetics 20231101 22
Mutations in genes encoding nuclear pore proteins (NUPs) lead to the development of steroid-resistant nephrotic syndrome and focal segmental glomerulosclerosis (FSGS). However, the precise molecular mechanisms by which NUP dysfunction contributes to podocyte injury preceding FSGS remain unclear. The tightly regulated activity of Yes-associated protein (YAP) and WW-domain-containing transcription regulator 1 (TAZ), the transcriptional effectors of the Hippo pathway, is crucial for podocytes and t ...[more]