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Intracellular peptides identified in plasma from SARS-CoV-2 infected patients

ABSTRACT: Intracellular peptides (InPeps), generated by the orchestrated action of the proteasome and intracellular peptidases, were suggested to have both biological and pharmacological significance as G-protein coupled receptors (GPCR) agonists or inverse agonists. InPeps profile alters whenever there is a challenge or associated disease. In the present study, the relative concentration of InPeps was investigated in patients infected or not with SARS-CoV-2 virus. Altogether, the present results suggest variation of plasma relative concentration of specific InPeps, in a group of patients infected with SARS-CoV-2 virus compared to SARS-CoV-2 non-infected patients. Therefore, it is exciting to suggest that human plasma have InPeps that may be playing a yet unknown function in SARS-CoV-2 virus infection.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Severe Acute Respiratory Syndrome

SUBMITTER: Luiz Felipe Martucci

LAB HEAD: Emer Suavinho Ferro

PROVIDER: PXD040580 | Pride | 2023-04-19

REPOSITORIES: Pride

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