Dataset Information
Identification of inhibitors for the trans-membrane Trypanosoma cruzi eIF2alpha kinase relevant for parasite proliferation
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Trypanosoma Cruzi
TISSUE(S): Permanent Cell Line Cell, Cell Culture
DISEASE(S): Chagas Disease
SUBMITTER: 
Sergio Schenkman
LAB HEAD: Sergio Schenkman
PROVIDER: PXD040597 | Pride | 2023-07-20
REPOSITORIES: Pride
Publications
Identification of inhibitors for the transmembrane Trypanosoma cruzi eIF2α kinase relevant for parasite proliferation.
The Journal of biological chemistry 20230523 7
The TcK2 protein kinase of Trypanosoma cruzi, the causative agent of Chagas disease, is structurally similar to the human kinase PERK, which phosphorylates the initiation factor eIF2α and, in turn, inhibits translation initiation. We have previously shown that absence of TcK2 kinase impairs parasite proliferation within mammalian cells, positioning it as a potential target for treatment of Chagas disease. To better understand its role in the parasite, here we initially confirmed the importance o ...[more]
