Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Neuroblastoma Cell Line
SUBMITTER: Samiksha Sardana
LAB HEAD: Marc Pieter Baggelaar
PROVIDER: PXD040613 | Pride | 2023-10-24
REPOSITORIES: Pride
Sardana Samiksha S Nederstigt Anneroos E AE Baggelaar Marc P MP
Journal of proteome research 20230609 7
<i>S</i>-Palmitoylation is the covalent attachment of C14:0-C22:0 fatty acids (mainly C16:0 palmitate) to cysteines via thioester bonds. This lipid modification is highly abundant in neurons, where it plays a role in neuronal development and is implicated in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. The knowledge of <i>S</i>-palmitoylation in neurodevelopment is limited due to technological challenges in analyzing this highly hydropho ...[more]