DIA proteomics on mouse tissue to investigate the GAPDH redox switch

ABSTRACT: The glycolytic enzyme GAPDH is equipped with a redox switch that rapidly and reversibly inactivates the enzyme in the presence of hydrogen peroxide. The physiological implications of the redox switch were investigated in C57BL/6NTac wildtype and GAPDH(T175A) knock-in mice generated by CRISPR/Cas9 genome editing.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart, Kidney

SUBMITTER: Justus L. Großmann  

LAB HEAD: Markus Ralser

PROVIDER: PXD040620 | Pride | 2023-04-10

REPOSITORIES: Pride