Identifying Targets of Pyrvinium Pamoate in Jurkat Cells using PISA

ABSTRACT: Pyrvinium pamoate, an anthelmintic drug, inhibits mitochondrial biogenesis during initial T-cell activation; however, its molecular target(s) and mechanism of action are unknown. In this study, we treated Jurkat T cell lysate with pyrvinium pamoate (5 nM and 50μM) and used proteome integral solubility alteration (PISA), to identify potential targets.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): T Cell, Jurkat Cell

SUBMITTER: Brandon Gassaway  

LAB HEAD: Steven Gygi

PROVIDER: PXD040663 | Pride | 2023-08-29

REPOSITORIES: Pride