Proteomics

Dataset Information

0

Identifying Targets of Pyrvinium Pamoate in Jurkat Cells using PISA


ABSTRACT: Pyrvinium pamoate, an anthelmintic drug, inhibits mitochondrial biogenesis during initial T-cell activation; however, its molecular target(s) and mechanism of action are unknown. In this study, we treated Jurkat T cell lysate with pyrvinium pamoate (5 nM and 50μM) and used proteome integral solubility alteration (PISA), to identify potential targets.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): T Cell, Jurkat Cell

SUBMITTER: Brandon Gassaway  

LAB HEAD: Steven Gygi

PROVIDER: PXD040663 | Pride | 2023-08-29

REPOSITORIES: Pride

Similar Datasets

2011-07-06 | E-GEOD-30404 | biostudies-arrayexpress
2023-03-29 | PXD040703 | Pride
2021-07-10 | E-MTAB-10700 | biostudies-arrayexpress
2016-02-12 | E-GEOD-76456 | biostudies-arrayexpress
2021-01-08 | PXD021961 | Pride
2022-06-05 | PXD026529 | Pride
2008-09-01 | E-MEXP-1430 | biostudies-arrayexpress
2007-11-10 | E-MEXP-1234 | biostudies-arrayexpress
2018-08-16 | PXD009945 | Pride
2016-07-26 | E-GEOD-50566 | biostudies-arrayexpress