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Proteomic profiling identifies ITIH3 as a biomarker for disease activity in myasthenia gravis

ABSTRACT: Myasthenia gravis (MG) is a chronic antibody-mediated autoimmune disease disrupting neuromuscular synaptic transmission. Antibodies (Abs) against the acetylcholine receptor (AChR) are detected in approximately 85% of patients. Here, we aimed to study the serum proteome of MG and to identify novel biomarkers reflecting disease activity.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Andreas Hentschel

LAB HEAD: Tobias Ruck

PROVIDER: PXD040786 | Pride | 2023-10-24

REPOSITORIES: Pride

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Eculizumab treatment alters the proteometabolome beyond the inhibition of complement.

Nelke Christopher C Schroeter Christina B CB Stascheit Frauke F Huntemann Niklas N Pawlitzki Marc M Willison Alice A Räuber Saskia S Melzer Nico N Distler Ute U Tenzer Stefan S Stühler Kai K Roos Andreas A Meisel Andreas A Meuth Sven G SG Ruck Tobias T

JCI insight 20230710 13

Therapeutic strategies targeting complement have revolutionized the treatment of myasthenia gravis (MG). However, a deeper understanding of complement modulation in the human system is required to improve treatment responses and identify off-target effects shaping long-term outcomes. For this reason, we studied a cohort of patients with MG treated with either eculizumab or azathioprine as well as treatment-naive patients using a combined proteomics and metabolomics approach. This strategy valida ...[more]

PMID: 37227781

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