Osteosarcoma cells-derived secretome induce pre-metastatic changes in the lung microenvironment that support lung metastasis formation
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Culture Fluid
SUBMITTER: 
Ana Sofia Ribeiro
LAB HEAD: Célia Gomes
PROVIDER: PXD040814 | Pride | 2024-01-26
REPOSITORIES: Pride
Publications
Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling.
Almeida Sara F F SFF Santos Liliana L Sampaio-Ribeiro Gabriela G Ferreira Hugo R S HRS Lima Nuno N Caetano Rui R Abreu Mónica M Zuzarte Mónica M Ribeiro Ana Sofia AS Paiva Artur A Martins-Marques Tânia T Teixeira Paulo P Almeida Rui R Casanova José Manuel JM Girão Henrique H Abrunhosa Antero J AJ Gomes Célia M CM
Journal of experimental & clinical cancer research : CR 20231130 1
<h4>Background</h4>Lung metastasis is the most adverse clinical factor and remains the leading cause of osteosarcoma-related death. Deciphering the mechanisms driving metastatic spread is crucial for finding open therapeutic windows for successful organ-specific interventions that may halt or prevent lung metastasis.<h4>Methods</h4>We employed a mouse premetastatic lung-based multi-omics integrative approach combined with clinical features to uncover the specific changes that precede lung metast ...[more]
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