Dataset Information

Elevated plasma Complement Factor H Regulating Protein 5 is associated with venous thromboembolism

ABSTRACT: Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious short- and long-term complications. In clinical practice, there is a need for improved plasma biomarker-based tools for VTE diagnosis and risk prediction. We use multiplex proteomics profiling to screen plasma from patients with suspected acute VTE, and several case-control studies for VTE, to identify Complement Factor H Related Protein 5 (CFHR5), a regulator of the alternative pathway of complement activation, as a novel VTE associated plasma biomarker. In plasma, higher CFHR5 levels are associated with increased thrombin generation potential and recombinant CFHR5 enhanced platelet activation in vitro. GWAS analysis of ~52,000 participants identifies six loci associated with CFHR5 plasma levels, but Mendelian randomization do not demonstrate causality between CFHR5 and VTE. Our results indicate an important role for the regulation of the alternative pathway of complement activation in VTE and that CFHR5 represents a potential diagnostic and/or risk predictive plasma biomarker.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: David Kotol

LAB HEAD: Jacob Odeberg

PROVIDER: PXD040913 | Pride | 2023-03-25

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	All_lists_20190625_20190709.fasta	Fasta
	HF_20200720_VEBIOS_DIA_350to1000mz_40min_1to32_10mz_A1.raw	Raw
	HF_20200720_VEBIOS_DIA_350to1000mz_40min_1to32_10mz_A10.raw	Raw
	HF_20200720_VEBIOS_DIA_350to1000mz_40min_1to32_10mz_A11.raw	Raw
	HF_20200720_VEBIOS_DIA_350to1000mz_40min_1to32_10mz_A12.raw	Raw

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Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.

Iglesias Maria Jesus MJ Sanchez-Rivera Laura L Ibrahim-Kosta Manal M Naudin Clément C Munsch Gaëlle G Goumidi Louisa L Farm Maria M Smith Philip M PM Thibord Florian F Kral-Pointner Julia Barbara JB Hong Mun-Gwan MG Suchon Pierre P Germain Marine M Schrottmaier Waltraud W Dusart Philip P Boland Anne A Kotol David D Edfors Fredrik F Koprulu Mine M Pietzner Maik M Langenberg Claudia C Damrauer Scott M SM Johnson Andrew D AD Klarin Derek M DM Smith Nicholas L NL Smadja David M DM Holmström Margareta M Magnusson Maria M Silveira Angela A Uhlén Mathias M Renné Thomas T Martinez-Perez Angel A Emmerich Joseph J Deleuze Jean-Francois JF Antovic Jovan J Soria Fernandez Jose Manuel JM Assinger Alice A Schwenk Jochen M JM Souto Andres Joan Carles JC Morange Pierre-Emmanuel PE Butler Lynn Marie LM Trégouët David-Alexandre DA Odeberg Jacob J

Nature communications 20230607 1

Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious short- and long-term complications. In clinical practice, there is a need for improved plasma biomarker-based tools for VTE diagnosis and risk prediction. Here we show, using proteomics profiling to screen plasma from patients with suspected acute VTE, and several case-control studies for VTE, how Complement Factor H Related 5 protein (CFHR5), a regulator of the alternative pathway of complement activation, i ...[more]

PMID: 37286573

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