Dataset Information

LExtracellular vesicle proteins of E. coli O83

ABSTRACT: EcO83-Outer membrane vesicles (OMVs) were isolated by ultracentrifugation and characterised with respect to their number, morphology, composition of lipopolysaccharide and proteins, as well as immunomodulatory potential.

INSTRUMENT(S):

ORGANISM(S): Escherichia Coli

TISSUE(S): Cell Suspension Culture

SUBMITTER: Johan Palmfeldt

LAB HEAD: Johan Palmfeldt

PROVIDER: PXD040963 | Pride | 2024-05-24

REPOSITORIES: Pride

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Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice.

Schmid Anna Marlene AM Razim Agnieszka A Wysmołek Magdalena M Kerekes Daniela D Haunstetter Melissa M Kohl Paul P Brazhnikov Georgii G Geissler Nora N Thaler Michael M Krčmářová Eliška E Šindelář Martin M Weinmayer Tamara T Hrdý Jiří J Schmidt Katy K Nejsum Peter P Whitehead Bradley B Palmfeldt Johan J Schild Stefan S Inić-Kanada Aleksandra A Wiedermann Ursula U Schabussova Irma I

Cell communication and signaling : CCS 20231020 1

<h4>Background</h4>E. coli O83 (Colinfant Newborn) is a Gram-negative (G-) probiotic bacterium used in the clinic. When administered orally, it reduces allergic sensitisation but not allergic asthma. Intranasal administration offers a non-invasive and convenient delivery method. This route bypasses the gastrointestinal tract and provides direct access to the airways, which are the target of asthma prevention. G- bacteria such as E. coli O83 release outer membrane vesicles (OMVs) to communicate w ...[more]

PMID: 37864211

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	401-Brad-1-OMV-A.raw	Raw
	403-Brad-4-con-OMV-A.raw	Raw
	405-Brad-Coli-A.raw	Raw
	407-Brad-2-OMV-B.raw	Raw
	409-Brad-5-con-OMV-B.raw	Raw