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Human hepatocellular carcinoma Orbitrap-LC-MS-HZ

ABSTRACT: Human hepatocellular carcinoma cells were subcutaneously implanted into nude mice and treated with photodynamic nanoparticles (NP3) with laser, followed by tissue collection and proteomic analysis.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Liver

SUBMITTER: Huiling Zhou

LAB HEAD: Haihua Xiao

PROVIDER: PXD041112 | Pride | 2023-10-24

REPOSITORIES: Pride

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Publications

Theranostic imaging and multimodal photodynamic therapy and immunotherapy using the mTOR signaling pathway.

Zhou Huiling H Tang Dongsheng D Yu Yingjie Y Zhang Lingpu L Wang Bin B Karges Johannes J Xiao Haihua H

Nature communications 20230902 1

Tumor metastases are considered the leading cause of cancer-associated deaths. While clinically applied drugs have demonstrated to efficiently remove the primary tumor, metastases remain poorly accessible. To overcome this limitation, herein, the development of a theranostic nanomaterial by incorporating a chromophore for imaging and a photosensitizer for treatment of metastatic tumor sites is presented. The mechanism of action reveals that the nanoparticles are able to intervene by local genera ...[more]

PMID: 37660174

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