Proteomic profiling of eIF3a conditional knockout mice

ABSTRACT: In this study, a Cre-loxP system was used to generate eIF3a conditional knockout mice. Tandem mass tag (TMT) labeling with LC-MS/MS analysis was used to identify differentially expressed proteins (DEPs) in fat, lungs, skin, and spleen tissue of the eIF3a knockout mice and controls. Bioinformatics analysis was then used to explore the functions and molecular signaling pathways of these protein landscapes.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Spleen, Lung, Skin

SUBMITTER: Wei Zhuo  

LAB HEAD: Zhaoqian Liu

PROVIDER: PXD041416 | Pride | 2023-07-20

REPOSITORIES: pride