Dataset Information

Using HDX-MS to study Rab and Ral covalently bound to MRTX1257

ABSTRACT: Here we use HDX to study covalently modified Rab1a and RalA in both their apo states and bound to MRTX1257 to see how this compound affects the overall secondary structure of the proteins.

INSTRUMENT(S): impact HD

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: John Burke

LAB HEAD: John Burke

PROVIDER: PXD041440 | Pride | 2025-03-10

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	03_21_23_JEHDX7_Rab_MSMS_2Pep_0_01_21793.d.rar	Other
	03_22_23_JEHDX7_RalA_C_300s_1_0_01_21758.d.rar	Other
	03_22_23_JEHDX7_RalA_C_30s_1_0_01_21754.d.rar	Other
	03_22_23_JEHDX7_RalA_C_3s_1_0_01_21750.d.rar	Other
	03_22_23_JEHDX7_RalA_ND_0_01_21744.d.rar	Other

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1 - 5 of 68

Publications

Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket.

Morstein Johannes J Bowcut Victoria V Fernando Micah M Yang Yue Y Zhu Lawrence L Jenkins Meredith L ML Evans John T JT Guiley Keelan Z KZ Peacock D Matthew DM Krahnke Sophie S Lin Zhi Z Taran Katrine A KA Huang Benjamin J BJ Stephen Andrew G AG Burke John E JE Lightstone Felice C FC Shokat Kevan M KM

Cell 20240909 22

The family of Ras-like GTPases consists of over 150 different members, regulated by an even larger number of guanine exchange factors (GEFs) and GTPase-activating proteins (GAPs) that comprise cellular switch networks that govern cell motility, growth, polarity, protein trafficking, and gene expression. Efforts to develop selective small molecule probes and drugs for these proteins have been hampered by the high affinity of guanosine triphosphate (GTP) and lack of allosteric regulatory sites. Th ...[more]

PMID: 39255801

Dataset Information

Using HDX-MS to study Rab and Ral covalently bound to MRTX1257

Dataset's files

Publications

Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket.

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