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Burkholderia thailandensis stress response to 12-bis-THA

ABSTRACT: Examination of the 12-bis-THA stress response in Burkholderia thailandensis strain E555 to investigate its antimicrobial mechanism of action

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Burkholderia Thailandensis E555

SUBMITTER: Adam Pattinson

LAB HEAD: Professor Michael McArthur

PROVIDER: PXD041456 | Pride | 2023-07-20

REPOSITORIES: Pride

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Using a multi-omic approach to investigate the mechanism of 12-bis-THA activity against Burkholderia thailandensis.

Pattinson Adam A Bahia Sandeep S Le Gall Gwénaëlle G Morris Christopher J CJ Harding Sarah V SV McArthur Michael M

Frontiers in microbiology 20230512

Burkholderia pseudomallei is the causative agent of the tropical disease, melioidosis. It is intrinsically resistant to many antimicrobials and treatment requires an onerous regimen of intravenous and orally administered drugs. Relapse of disease and high rates of mortality following treatment are common, demonstrating the need for new anti-Burkholderia agents. The cationic bola-amphiphile, 12,12'-(dodecane-1,12-diyl) bis (9-amino-1,2,3,4-tetrahydroacridinium), referred to as 12-bi ...[more]

PMID: 37252207

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