Dataset Information
Proteome-Broad phosphorylation mediated by testis-specific serine/threonine kinases contributes to spermiogenesis and male fertility
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Drosophila Melanogaster (fruit Fly)
TISSUE(S): Testis
SUBMITTER: 
Xuedi Zhang
LAB HEAD: Guanjun Gao
PROVIDER: PXD041466 | Pride | 2023-07-20
REPOSITORIES: Pride
Publications
Broad phosphorylation mediated by testis-specific serine/threonine kinases contributes to spermiogenesis and male fertility.
Nature communications 20230506 1
Genetic studies elucidate a link between testis-specific serine/threonine kinases (TSSKs) and male infertility in mammals, but the underlying mechanisms are unclear. Here, we identify a TSSK homolog in Drosophila, CG14305 (termed dTSSK), whose mutation impairs the histone-to-protamine transition during spermiogenesis and causes multiple phenotypic defects in nuclear shaping, DNA condensation, and flagellar organization in spermatids. Genetic analysis demonstrates that kinase catalytic activity o ...[more]
