Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The Cyclimids: Degron-inspired cereblon binders for targeted protein degradation

ABSTRACT: Our studies establish the unique properties of the cyclimids as versatile warheads in TPD and a systematic biochemical approach for quantifying ternary complex formation to predict their cellular degradation activity, which together will accelerate the development of novel CRBN-targeting bifunctional degraders.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): T Cell

SUBMITTER: Christina Woo

LAB HEAD: Christina Woo

PROVIDER: PXD041494 | Pride | 2024-01-26

REPOSITORIES: Pride

ACCESS DATA

Json Xml

Similar Datasets

Transcription profiling of tissue from different developmental stages and parts of Arabidopsis Col0 and Ler0 wild type and gcn2 mutant plants

Project description:1- Comparison of the transcriptome of two ecotypes (Col0 and Ler0): compare the transcriptome of ColO versus Ler0 for different tissues and developmental stages (seedlings 7 days, shoot 14 days, flowers, leafs 35 days)<br> 2- Impact of SINE RNA : Analyse the consequence of the expression of a SINE RNA in Arabidopsis thaliana<br> 3- Impact of the gcn2 mutation : Impact of the gcn2 mutation on the Arabidopsis thaliana transcriptome. GCN2 is a kinase potentially regulated by the SINE non-coding RNA

2007-07-16 | E-MEXP-800 | biostudies-arrayexpress

Expression profiling of T.rubrum treated with PH11B

Project description:T. rubrum was treated with PH11B,a potent eucaryotic fatty acid synthase inhibtor. A cDNA microarray was constructed from the expressed sequence tags (ESTs) of different developmental stages, and transcriptional profiles of the responses to PH11B were determined. Some class-specific and mechanism-independent changes in gene expression were found. Keywords: fatty acid synthase inhibition The expression profiles of Trichophyton rubrum treated with PH11B were compared to those of Trichophyton rubrum without drug. Each treatment has three replicates.

2007-11-21 | E-GEOD-6336 | biostudies-arrayexpress

Expression profiling of T.rubrum treated with Terbinafine

Project description:One antifungal agent, terbinafine(TRB), has specific activity against dermatophytes.A cDNA microarray was constructed from the expressed sequence tags (ESTs) of different developmental stages, and transcriptional profiles of the responses to TRB were determined. Some class-specific and mechanism-independent changes in gene expression were found. Keywords: original article The expression profiles of Trichophyton rubrum treated with TRB were compared to those of Trichophyton rubrum without drug. Each treatment has three replicates.

2010-06-26 | E-GEOD-6951 | biostudies-arrayexpress

Expression of seaweed genes induced by perwinkle grazing

Project description:The aim of this study was to elucidate changes in gene expression related to the induced anti-herbivory response in the brown seaweed Fucus vesiculosus. Microarray hybridizations were used to identify genes differentially expressed in response to grazing by the periwinkle Littorina obtusata. This study shows that modifications in gene expression occur simultaneously to a reduced palatability and that defence induction entails reallocation of resources from primary to secondary metabolism with down-regulation of photosynthesis. Total RNA of Fucus vesiculosus pieces that were or were not previously grazed by Littorina obtusata for 3, 12, 15, 21, and 24 days (5 biological replicates each) was hybridized against pooled RNA from 5 F. vesiculosus pieces that were collected before onset of grazing (day 0).

2013-12-13 | E-GEOD-53262 | biostudies-arrayexpress

Genome-wide analysis of p53 binding protein

Project description:Tumor suppressor p53 regulates various role in the cell including cell cycle arrest, DNA repair and apoptosis. Current research achieved to investigate p53 target genes in human osteosarcoma cell line-SaOS2 cell. Examination of p53 binding protein by transfecting flag-tagged wild type p53 into SaOS2 cells.

2014-04-01 | E-GEOD-51268 | biostudies-arrayexpress

Grazing-induced expression of seaweed genes

Project description:The aim of this study was to elucidate which changes in gene expression are related to the induced anti-herbivory response in the brown seaweed Fucus vesiculosus. Microarray hybridizations were used to identify genes differentially expressed in response to grazing by the isopod Idotea baltica. This study shows that modifications in gene expression occur simultaneously to a reduced palatability and that defence induction entails reallocation of resources from primary to secondary metabolism with down-regulation of photosynthesis and degradation of storage compounds. Total RNA of Fucus vesiculosus pieces that were or were not previously grazed by Idotea baltica for 15 and 18 days (3 biological replicates each) was hybridized against pooled RNA from 4 F. vesiculosus pieces that were collected before onset of grazing (day 0).

2013-06-19 | E-GEOD-47975 | biostudies-arrayexpress

rogB mutant in NEM316 S. agalactiae strain

Project description:transcritpomic analysis of rogB mutant in NEM316 S. agalactiae strain

2012-05-21 | E-MEXP-3237 | biostudies-arrayexpress

rga response

Project description:comparison of the transcriptionnal response of the rga mutant and the wild type in S. agalactiae NEM316 strain

2012-05-21 | E-MEXP-3236 | biostudies-arrayexpress

CovRS response in S. agalactiae NEM316 strain

Project description:Analysis of the CovRS response in S. agalactiae NEM316 strain with microarrays

2012-05-21 | E-MEXP-3304 | biostudies-arrayexpress

Impact of RelRS and CiaRH deletion in transcription profiling in a wild-type background

Project description:Impact of two TCS RelRS and CiaRH deletion in transcription profiling in a wild-type background