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LINC00955 Suppresses Colorectal Cancer Growth by Acting as a Molecular Scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated Methylation of the PHIP Promoter-nanoLCMS/MS analysis

ABSTRACT: To assess direct involvement of LINC00955 in regulation of gene expression, LINC00955 was used as an RNA probe in RNA pull-down assays and mass spectrometry analyses.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Gnglin Ren

LAB HEAD: Gnglin Ren

PROVIDER: PXD041514 | Pride | 2023-10-24

REPOSITORIES: Pride

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LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter.

Ren Ganglin G Li Hongyan H Hong Dan D Hu Fangyu F Jin Rongjia R Wu Shuang S Sun Wenhao W Jin Honglei H Zhao Lingling L Zhang Xiaodong X Liu Dongxiang D Huang Chuanshu C Huang Haishan H

BMC cancer 20230923 1

<h4>Background</h4>Long non-coding RNAs play an important role in the development of colorectal cancer (CRC), while many CRC-related lncRNAs have not yet been identified.<h4>Methods</h4>The relationship between the expression of LINC00955 (Long Intergenic Non-protein Coding RNA 955) and the prognosis of colorectal cancer patients was analyzed using the sequencing results of the TCGA database. LINC00955 expression levels were measured using qRT-PCR. The anti-proliferative activity of LINC00955 wa ...[more]

PMID: 37742010

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