PXD041516 - Excretory-secretory proteome of nematode Heligmosomoides polygyrus developed in colitic conditions

Dataset Information

Excretory-secretory proteome of nematode Heligmosomoides polygyrus developed in colitic conditions

ABSTRACT: The aim of the study was to evaluate excretory-secretory protein set produced by nematode H. polygyrus L4 stage male and female developed in colitic milienu. Mass spectrometry was used to identify proteins. OmicsBox was used to investigate the functions of the discovered proteins.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Heligmosomoides Polygyrus Bakeri

TISSUE(S): Whole Body

DISEASE(S): Colitis

SUBMITTER: Ludmiła Szewczak

LAB HEAD: Katarzyna Donskow-Łyskoniewska

PROVIDER: PXD041516 | Pride | 2023-10-24

REPOSITORIES: Pride

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Publications

The Impact of Intestinal Inflammation on Nematode's Excretory-Secretory Proteome.

Maruszewska-Cheruiyot Marta M Szewczak Ludmiła L Krawczak-Wójcik Katarzyna K Kierasińska Magdalena M Stear Michael M Donskow-Łysoniewska Katarzyna K

International journal of molecular sciences 20230915 18

Parasitic nematodes and their products are promising candidates for therapeutics against inflammatory bowel diseases (IBD). Two species of nematodes, the hookworm Necator americanus and the whipworm Trichuis suis, are being used in clinical treatment trials of IBD referred to as "helminth therapy". Heligmosomoides polygyrus is a well-known model for human hookworm infections. Excretory-secretory (ES) products of H. polygyrus L4 stage that developed during colitis show ...[more]

PMID: 37762428

Dataset Information

Excretory-secretory proteome of nematode Heligmosomoides polygyrus developed in colitic conditions

Publications

The Impact of Intestinal Inflammation on Nematode's Excretory-Secretory Proteome.

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