Excretory-secretory proteome of nematode Heligmosomoides polygyrus developed in colitic conditions
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Heligmosomoides Polygyrus Bakeri
TISSUE(S): Whole Body
DISEASE(S): Colitis
SUBMITTER: 
Ludmiła Szewczak
LAB HEAD: Katarzyna Donskow-Łyskoniewska
PROVIDER: PXD041516 | Pride | 2023-10-24
REPOSITORIES: Pride
Publications
The Impact of Intestinal Inflammation on Nematode's Excretory-Secretory Proteome.
Maruszewska-Cheruiyot Marta M Szewczak Ludmiła L Krawczak-Wójcik Katarzyna K Kierasińska Magdalena M Stear Michael M Donskow-Łysoniewska Katarzyna K
International journal of molecular sciences 20230915 18
Parasitic nematodes and their products are promising candidates for therapeutics against inflammatory bowel diseases (IBD). Two species of nematodes, the hookworm <i>Necator americanus</i> and the whipworm <i>Trichuis suis</i>, are being used in clinical treatment trials of IBD referred to as "helminth therapy". <i>Heligmosomoides polygyrus</i> is a well-known model for human hookworm infections. Excretory-secretory (ES) products of <i>H. polygyrus</i> L4 stage that developed during colitis show ...[more]
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