Proteomics

Dataset Information

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Plasma N-Glycoproteomics for BMI-discordant monozygotic twin pairs

ABSTRACT: The aim of the project was to identify altered plasma proteins and altered plasma N-glycopeptides from monozygotic twin pairs who are discordant for body weight. We performed targeted quantitative N-glycoproteomics from plasma samples from 48 twin pairs (n = 96 individuals). This is the N-Glycopeptidomics part of the project. Proteomics of the same project has the accession number of PXD041384.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Obesity

SUBMITTER: Sakari Joenväärä  

LAB HEAD: Professor Risto Renkonen

PROVIDER: PXD041584 | Pride | 2025-05-06

REPOSITORIES: Pride

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Dataset's files

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20220207_GP_SEC_PIETILAINEN_02.raw.zip Raw
20220207_GP_SEC_PIETILAINEN_03.raw.zip Raw
20220207_GP_SEC_PIETILAINEN_04.raw.zip Raw
20220207_GP_SEC_PIETILAINEN_05.raw.zip Raw
20220207_GP_SEC_PIETILAINEN_06.raw.zip Raw
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Publications

Plasma N-Glycoproteomics in monozygotic twin pairs discordant for body mass index reveals an obesity signature related to inflammation and iron metabolism.

Muniandy Maheswary M   Joenväärä Sakari S   van der Kolk Birgitta W BW   Tohmola Tiialotta T   Haltia Hanna H   Saari Sina S   Hakkarainen Antti A   Lundbom Jesper J   Kuula Juho J   Groop Per-Henrik PH   Kaprio Jaakko J   Heinonen Sini S   Renkonen Risto R   Pietiläinen Kirsi H KH  

Biology direct 20250319 1

<h4>Background</h4>N-glycosylation is a complex, post-translational modification which influences protein function and is sensitive to physiological changes. Obesity is associated with alterations in protein function; however, little is known about the glycoproteome in obesity beyond observations of association with types and structures of selected glycopeptides. Most often, due to technical challenges, glycan composition and structure information are missing. Here, we combined label-free data-i  ...[more]

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