Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite, Q Exactive
ORGANISM(S): Rattus Norvegicus (rat) Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Alexander Haupt
LAB HEAD: Prof. Dr. Bernd Fakler
PROVIDER: PXD041655 | Pride | 2024-03-13
REPOSITORIES: Pride
Boudkkazi Sami S Schwenk Jochen J Nakaya Naoki N Brechet Aline A Kollewe Astrid A Harada Harumi H Bildl Wolfgang W Kulik Akos A Dong Lijin L Sultana Afia A Zolles Gerd G Schulte Uwe U Tomarev Stanislav S Fakler Bernd B
Neuron 20230801 16
Information processing and storage in the brain rely on AMPA-receptors (AMPARs) and their context-dependent dynamics in synapses and extra-synaptic sites. We found that distribution and dynamics of AMPARs in the plasma membrane are controlled by Noelins, a three-member family of conserved secreted proteins expressed throughout the brain in a cell-type-specific manner. Noelin tetramers tightly assemble with the extracellular domains of AMPARs and interconnect them in a network-like configuration ...[more]