Dataset Information
Label free quantitative proteomics analysis based on LC-MS in Caki-1 to reveal the pathways associated with ERRα in ccRCC
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Renal Cortical Epithelial Cell, Cell Culture
SUBMITTER: 
Chun Feng
LAB HEAD: Feng Chun
PROVIDER: PXD041739 | Pride | 2025-05-06
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Ctrl-1.raw | Raw | |||
| Ctrl-2.raw | Raw | |||
| Ctrl-3.raw | Raw | |||
| Sh-ERR2-1.raw | Raw | |||
| Sh-ERR2-2.raw | Raw |
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Publications
Hypoxia-triggered ERRα acetylation enhanced its oncogenic role and promoted progression of renal cell carcinoma by coordinating autophagosome-lysosome fusion.
Cell death & disease 20250116 1
Estrogen-related receptor α (ERRα) is dysregulated in many types of cancer and exhibits oncogenic activity by promoting tumorigenesis and metastasis of cancer cells. However, its defined role in renal cell carcinoma (RCC) has not been fully elucidated. To reveal the biological function of ERRα and determine the underlying regulatory mechanism in RCC, the quantitative proteomics analysis and mechanism investigation were conducted. The results demonstrated that ERRα promoted the proliferation and ...[more]
