Ochrogaster lunifer setae proteome

ABSTRACT: Ochrogaster lunifer (Lepidoptera: Notodontidae) is an Australian processionary caterpillar with detachable urticating setae that have a defensive function. These true setae induce inflammation when they contact human skin, and equine foetal loss syndrome if they are accidentally ingested by gravid horses. We used transcriptomics and proteomics to identify proteins and peptides present in and on urticating setae, which may include toxins that contribute to inflammation and/or foetal loss syndromes. This process identified 37 putative toxins, including multiple homologues of the honeybee venom peptide secapin, and proteins with similarity to odorant binding proteins, arylphorins, and the insect immune modulator Diedel. This work identifies candidate molecules that may contribute to the adverse effects of processionary caterpillar setae on human and animal health.

INSTRUMENT(S):

ORGANISM(S): Ochrogaster Lunifer

TISSUE(S): Cuticle

DISEASE(S): Inflammation

SUBMITTER: Andrew Walker  

LAB HEAD: Glenn King

PROVIDER: PXD041864 | Pride | 2024-07-30

REPOSITORIES: Pride