Dataset Information

Bile acids at host-Enterobacteriaceae interface

ABSTRACT: The intestinal mucosa of inflammatory bowel disease (IBD) patients is enriched with Enterobacteriaceae members. Concurrently, there is elevated bile acid (BA) bioavailability in the colons of IBD patients. Whether enhanced BA levels contribute to the bloom of Enterobacteriaceae members in IBD patients remains unexplored.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Colon

DISEASE(S): Crohn's Disease

SUBMITTER: Jenny Moon

LAB HEAD: Leonard J. Foster

PROVIDER: PXD041934 | Pride | 2025-10-07

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	2022-04-28-decoys-contam-uniprot-Human_Reviewed.fasta.fas	Fasta
	FragPipe-18.0.zip	Other
	MSFragger-3.5.7z	Other
	MaxQuant_2.1.0.0.zip	Other
	Ravi-C01C-100ng_6-24-2022_Slot1-26_1275.d.1.dar	Other

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Publications

Bile acid-induced metabolic changes in the colon promote Enterobacteriaceae expansion and associate with dysbiosis in Crohn's disease.

Holani Ravi R Bar-Yoseph Haggai H Krekhno Zakhar Z Serapio-Palacios Antonio A Moon Kyung-Mee KM Stacey Richard G RG Donald Katherine A KA Deng Wanyin W Bressler Brian B Magaña Armando A AA Foster Leonard J LJ Atser Michael G MG Johnson James D JD Finlay Barton B

Science signaling 20241217 867

Bile acids (BAs) affect the growth of potentially pathogenic commensals, including those from the Enterobacteriaceae family, which are frequently overrepresented in inflammatory bowel disease (IBD). BAs are normally reabsorbed in the ileum for recycling and are often increased in the colonic lumina of patients with IBD, including those with Crohn's disease (CD). Here, we investigated the influence of BAs on gut colonization by Enterobacteriaceae. We found increased abundance of Enterobacteriacea ...[more]

PMID: 39689182

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