Suppression of PPARGC1A causes collateral sensitivity to HMGCR-inhibitor within BRAFi-treatement resistant melanoma

ABSTRACT: We aimed to identify the potential proteins as a collateral vulnerability within PGC1a-suppressed BRAF-inhibitor resistant melanomas, and the potential mechanisms behind this including their abundancy and cellular distribution.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Melanocyte

DISEASE(S): Melanoma And Neural System Tumor Syndrome

SUBMITTER: Haopeng Xiao  

LAB HEAD: Pere Puigserver

PROVIDER: PXD041952 | Pride | 2023-06-09

REPOSITORIES: Pride