Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Colon Cancer
SUBMITTER: Silvia Surinova
LAB HEAD: Silvia Surinova
PROVIDER: PXD041975 | Pride | 2023-05-04
REPOSITORIES: Pride
Porter Hayley H Li Yang Y Neguembor Maria Victoria MV Beltran Manuel M Varsally Wazeer W Martin Laura L Cornejo Manuel Tavares MT Pezić Dubravka D Bhamra Amandeep A Surinova Silvia S Jenner Richard G RG Cosma Maria Pia MP Hadjur Suzana S
eLife 20230403
Most studies of cohesin function consider the Stromalin Antigen (STAG/SA) proteins as core complex members given their ubiquitous interaction with the cohesin ring. Here, we provide functional data to support the notion that the SA subunit is not a mere passenger in this structure, but instead plays a key role in the localization of cohesin to diverse biological processes and promotes loading of the complex at these sites. We show that in cells acutely depleted for RAD21, SA proteins remain boun ...[more]