Proteome of group 2 innate lymphoid cells (ILC2s) stimulated with IL33 and TL1A

ABSTRACT: We analyzed the total proteome of group 2 innate lymphoid cells (ILC2s) after different stimulation with interleukin-33 (IL-33), a cytokine playing a critical role in human asthma, and TL1A, a TNF-family cytokine also known to activate ILC2s. Upon combined stimulation with IL-33 plus TL1A, we show that lung ILC2s produce high amounts of IL-9 and acquire a transient ‘ILC9’ phenotype. This phenotype is characterized by simultaneous production of large amounts of type 2 cytokines (IL-5, IL-13 and IL-9), induction of the IL-2 receptor CD25 (Il2ra), and of the transcription factors IRF4, JunB and BATF, that form immune-specific complexes known to induce IL-9 expression.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Primary Cell, Lung, Group 2 Innate Lymphoid Cell

SUBMITTER: Anne Gonzalez de Peredo  

LAB HEAD: Anne Gonzalez de Peredo

PROVIDER: PXD041987 | Pride | 2024-03-05

REPOSITORIES: Pride