Proteomics

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Quantitative proteomic analysis of gastric cancer cells treated by bifidobacterium infantis-mediated herpes simplex virus-TK/ganciclovir.

ABSTRACT: MKN-45 cells were treated with PBS, BF-TK, BF/GCV or BF-TK/GCV for 48 h (GCV, 167 µg/ml), respectively. BF-TK (n = 3), BF/GCV (n = 3) or BF-TK/GCV (n = 3) groups were analyzed in triplicate.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

SUBMITTER: yanxi shen  

LAB HEAD: yongping ma

PROVIDER: PXD042044 | Pride | 2023-10-24

REPOSITORIES: Pride

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Publications

<i>Bifidobacterium infantis</i>-Mediated Herpes Simplex Virus-TK/Ganciclovir Treatment Inhibits Cancer Metastasis in Mouse Model.

Wang Changdong C   Shen Yanxi Y   Ma Yongping Y  

International journal of molecular sciences 20230721 14

Previous studies have found that <i>Bifidobacterium infantis</i>-mediated herpes simplex virus-TK/ganciclovir (BF-TK/GCV) reduces the expression of VEGF and CD146, implying tumor metastasis inhibition. However, the mechanism by which BF-TK/GCV inhibits tumor metastasis is not fully studied. Here, we comprehensively identified and quantified protein expression profiling for the first time in gastric cancer (GC) cells MKN-45 upon BF-TK/GCV treatment using quantitative proteomics. A total of 159 an  ...[more]

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