Proteomics

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Borrelia PeptideAtlas: A proteome resource of common Borrelia burgdorferi isolates for Lyme community

ABSTRACT: Lyme disease is a result from an infection by the spirochete Borrelia burgdorferi, and is the leading vector-borne disease in North America. Due to the genomic and proteomic variability of different B. burgdorferi isolates, the study and further comparison of their proteome is key to understand the biology and infectivity of these spirochetes. Mass spectrometry-based proteomics was used to assemble peptide datasets of laboratory isolates B31, MM1, B31-ML23, and the infective isolates B31-5A4, B31-A3, and 297, as well as other public datasets, and is publicly available as the Borrelia PeptideAtlas (http://www.peptideatlas.org/builds/borrelia/). These datasets include information on total proteome, secretome, and membrane proteome of the B. burgdorferi.

INSTRUMENT(S): LTQ Orbitrap, Orbitrap Fusion Lumos, TripleTOF 5600, Q Exactive HF

ORGANISM(S): Borrelia Sp. Tag21

SUBMITTER: Helisa Wippel  

LAB HEAD: Robert Moritz

PROVIDER: PXD042072 | Pride | 2025-05-06

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
09272019-Borrelia_phospho_5A4.raw.gz Raw
2016-07-01_Borrelia_insoluble_freezeThawBeads_1uL.raw Raw
2016-07-01_Borrelia_insoluble_freezeThawBeads_5uL.raw Raw
2016-07-01_Borrelia_insoluble_freezeThaw_1uL.raw Raw
2016-07-01_Borrelia_insoluble_freezeThaw_5uL.raw Raw
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Publications

Lyme disease is caused by an infection with the spirochete Borrelia burgdorferi, and is the most common vector-borne disease in North America. B. burgdorferi isolates harbor extensive genomic and proteomic variability and further comparison of isolates is key to understanding the infectivity of the spirochetes and biological impacts of identified sequence variants. Here, we applied both transcriptome analysis and mass spectrometry-based proteomics to assemble peptide datasets of B. burgdorferi l  ...[more]

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