Cardiac Myofibrillogenesis is Spatiotemporally Modulated by the Molecular Chaperone UNC45B

ABSTRACT: Sarcomeres are fundamental to cardiac muscle contraction. Their impairment can elicit cardiomyopathies, leading causes of death worldwide. However, the molecular mechanism underlying sarcomere assembly remains obscure. We used human embryonic stem cell (hESC)-derived cardiomyocytes (CMs) to reveal step-wise spatiotemporal regulation of core cardiac myofibrillogenesis-associated proteins.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Heart Development, Cell Culture, Embryonic Stem Cell

DISEASE(S): Cardiomyopathy

SUBMITTER: Su-Yi Tsai  

LAB HEAD: Su-Yi Tsai

PROVIDER: PXD042075 | Pride | 2023-10-24

REPOSITORIES: Pride