Dataset Information

Evolution of Collagen IV chains. Dogfish Lens

ABSTRACT: Evolution of Collagen IV chains from ministeria to ctenophora to hagfish/dogfish.

INSTRUMENT(S):

ORGANISM(S): Squalus Acanthias

TISSUE(S): Lens

SUBMITTER: Sergei Chetyrkin

LAB HEAD: Sergei Chetyrkin

PROVIDER: PXD042111 | Pride | 2025-06-16

REPOSITORIES: pride

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			Action	DRS
	checksum.txt	Txt
	ss_2690_SC_060412p_Lens_01.RAW	Raw
	ss_2690_SC_060412p_Lens_01.pepXML	Pepxml
	ss_2690_SC_060412p_Lens_02.RAW	Raw
	ss_2690_SC_060412p_Lens_02.pepXML	Pepxml

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Publications

Collagen IV of basement membranes: I. Origin and diversification of COL4 genes enabling metazoan multicellularity, evolution, and adaptation.

Page-McCaw Patrick S PS Pokidysheva Elena N EN Darris Carl E CE Chetyrkin Sergei S Fidler Aaron L AL Gallup Julianna J Murawala Prayag P Hudson Julie K JK Boudko Sergei P SP Hudson Billy G BG

The Journal of biological chemistry 20250411 5

Collagen IV (Col-IV) is a major component of basement membranes, a specialized form of extracellular matrix that enabled the assembly of multicellular epithelial tissues. In mammals, Col-IV assembles from a family of six α-chains (α1-α6), forming three supramolecular scaffolds: Col-IVα121, Col-IVα345, and Col-IVα121-α556. The α-chains are encoded by six genes (COL4A1-6) that occur in pairs in a head-to-head arrangement. In Alport syndrome, variants in COL4A3, 4, ...[more]

PMID: 40220996

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