Proteomics

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Quantitative cellular proteome analysis of Fetal- and Adult-Derived MLL-Rearranged Leukemia

ABSTRACT: Infant and adult MLL-rearranged (MLLr) leukemia represents a disease with few treatment options and a dismal prognosis. Here, we present an in-depth proteomic characterization of in utero-initiated and adult-onset MLLr leukemia in a mouse model of MLL-ENL-mediated leukemogenesis. We characterize early proteomic events of MLL-ENL-mediated transformation in fetal and adult progenitors.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Hematopoietic Multipotent Progenitor Cell, Liver, Bone Marrow

DISEASE(S): Acute Leukemia

SUBMITTER: Sudip Ghosh  

LAB HEAD: Dr. Jenny Hansson

PROVIDER: PXD042249 | Pride | 2024-04-02

REPOSITORIES: Pride

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Publications

A complex interplay of intra- and extracellular factors regulates the outcome of fetal- and adult-derived MLL-rearranged leukemia.

Jassinskaja Maria M   Ghosh Sudip S   Watral Joanna J   Davoudi Mina M   Claesson Stern Melina M   Daher Ugarit U   Eldeeb Mohamed M   Zhang Qinyu Q   Bryder David D   Hansson Jenny J  

Leukemia 20240330 5

Infant and adult MLL1/KMT2A-rearranged (MLLr) leukemia represents a disease with a dismal prognosis. Here, we present a functional and proteomic characterization of in utero-initiated and adult-onset MLLr leukemia. We reveal that fetal MLL::ENL-expressing lymphomyeloid multipotent progenitors (LMPPs) are intrinsically programmed towards a lymphoid fate but give rise to myeloid leukemia in vivo, highlighting a complex interplay of intra- and extracellular factors in determining disease subtype. W  ...[more]

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