Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Quadriceps
SUBMITTER: David James
LAB HEAD: David Ernest James
PROVIDER: PXD042277 | Pride | 2023-07-31
REPOSITORIES: Pride
Masson Stewart W C SWC Madsen Søren S Cooke Kristen C KC Potter Meg M Vegas Alexis Diaz AD Carroll Luke L Thillainadesan Senthil S Cutler Harry B HB Walder Ken R KR Cooney Gregory J GJ Morahan Grant G Stöckli Jacqueline J James David E DE
eLife 20230726
Systems genetics has begun to tackle the complexity of insulin resistance by capitalising on computational advances to study high-diversity populations. 'Diversity Outbred in Australia (DOz)' is a population of genetically unique mice with profound metabolic heterogeneity. We leveraged this variance to explore skeletal muscle's contribution to whole-body insulin action through metabolic phenotyping and skeletal muscle proteomics of 215 DOz mice. Linear modelling identified 553 proteins that asso ...[more]