MOE silencing of DUX4 in FSHD and UASB myoblasts

ABSTRACT: Proteomic studies in facioscapulohumeral muscular dystrophy (FSHD) could offer new insight to disease mechanisms underpinned by post-transcriptional processes. We used stable isotope (deuterium oxide; D2O) labelling and peptide mass spectrometry to investigate the abundance and turnover rates of proteins in cultured muscle cells from 2 individuals affected by FSHD and their unaffected siblings (UASb). Cells were treated with or without MOE to silence DUX4

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Striated Visceral Muscle Cell, Cell Culture

DISEASE(S): Facioscapulohumeral Muscular Dystrophy

SUBMITTER: Jatin Burniston  

LAB HEAD: Jatin G Burniston

PROVIDER: PXD042374 | Pride | 2023-06-27

REPOSITORIES: Pride