Proteomics of Triple Negative Breast Cancer Cells Treated with SU056
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ABSTRACT: 1. Quantitative Proteomics: MDA-MB-231, MDA-MB-468, and MCF12A cells were treated with DMSO (vehicle control) or SU056 (novel small molecule drug candidate). Quantitative proteomics analysis was performed on cell lysates. 2. Cellular Thermal Shift Assay (CETSA): MDA-MB-231 cells were treated with DMSO or SU056 and incubated at different temperatures and protein differences in the resulting soluble and insoluble fractions were determined.3. Cellular Thermal Shift Assay (CETSA): MDA-MB-231 YBOX1 KD cells were treated with DMSO or SU056 and incubated at different temperatures and protein differences in the soluble fractions were determined.
INSTRUMENT(S): Orbitrap Eclipse, LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Breast, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Sharon Pitteri
LAB HEAD: Sharon Pitteri
PROVIDER: PXD042380 | Pride | 2024-04-04
REPOSITORIES: Pride
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