Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cell Culture
SUBMITTER: Eric Bonneil
LAB HEAD: Ana Cuenda
PROVIDER: PXD042626 | Pride | 2023-08-10
REPOSITORIES: Pride
Escós Alejandra A Diaz-Mora Ester E Pattison Michael M Fajardo Pilar P González-Romero Diego D Risco Ana A Martín-Gómez José J Bonneil Éric É Sonenberg Nahum N Jafarnejad Seyed Mehdi SM Sanz-Ezquerro Juan José JJ Ley Steven C SC Cuenda Ana A
eLife 20230717
Evidence implicating p38γ and p38δ (p38γ/p38δ) in inflammation are mainly based on experiments using <i>Mapk12/Mapk13</i>-deficient (p38γ/δKO) mice, which show low levels of TPL2, the kinase upstream of MKK1-ERK1/2 in myeloid cells. This could obscure p38γ/p38δ roles, since TPL2 is essential for regulating inflammation. Here, we generated a <i>Mapk12</i><sup>D171A/D171A</sup>/<i>Mapk13</i><sup>-/-</sup> (p38γ/δKIKO) mouse, expressing kinase-inactive p38γ and lacking p38δ. This mouse exhibited no ...[more]