Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance

ABSTRACT: CDC6 is an oncogenic protein whose expression level fluctuates during the cell cycle. Although several E3 ubiquitin ligases responsible for the ubiquitin-mediated proteolysis of CDC6 have been identified, the deubiquitination pathway for CDC6 has not been investigated. Here, we report that OTUD6A functions as a deubiquitinase of CDC6. OTUD6A promotes cell proliferation and decreases sensitivity to chemotherapy by upregulating CDC6 protein expression.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: xc liu  

LAB HEAD: Jianfeng Cui

PROVIDER: PXD042935 | Pride | 2024-05-24

REPOSITORIES: Pride