RNA interactome capture analysis of mouse male germ cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Testis
SUBMITTER: 
Yueshuai Guo
LAB HEAD: xuejiang guo
PROVIDER: PXD043074 | Pride | 2025-10-29
REPOSITORIES: Pride
Dataset's files
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Publications
The landscape of RNA binding proteins in mammalian spermatogenesis.
Li Yang Y Wang Yuanyuan Y Tan Yue-Qiu YQ Yue Qiuling Q Guo Yueshuai Y Yan Ruoyu R Meng Lanlan L Zhai Huicong H Tong Lingxiu L Yuan Zihan Z Li Wu W Wang Cuicui C Han Shenglin S Ren Sen S Yan Yitong Y Wang Weixu W Gao Lei L Tan Chen C Hu Tongyao T Zhang Hao H Liu Liya L Yang Pinglan P Jiang Wanyin W Ye Yiting Y Tan Huanhuan H Wang Yanfeng Y Lu Chenyu C Li Xin X Xie Jie J Yuan Gege G Cui Yiqiang Y Shen Bin B Wang Cheng C Guan Yichun Y Li Wei W Shi Qinghua Q Lin Ge G Ni Ting T Sun Zheng Z Ye Lan L Vourekas Anastasios A Guo Xuejiang X Lin Mingyan M Zheng Ke K
Science (New York, N.Y.) 20241025 6720
Despite continuous expansion of the RNA binding protein (RBP) world, there is a lack of systematic understanding of RBPs in the mammalian testis, which harbors one of the most complex tissue transcriptomes. We adapted RNA interactome capture to mouse male germ cells, building an RBP atlas characterized by multiple layers of dynamics along spermatogenesis. Trapping of RNA-cross-linked peptides showed that the glutamic acid-arginine (ER) patch, a residue-coevolved polyampholytic element present in ...[more]
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