Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 240
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Bushra Ateeq
LAB HEAD: Dr. Bushra Ateeq
PROVIDER: PXD043086 | Pride | 2024-02-26
REPOSITORIES: Pride
iScience 20240104 3
Elevated serine peptidase inhibitor, Kazal type 1 (SPINK1) levels in ∼10%-25% of prostate cancer (PCa) patients associate with aggressive phenotype, for which there are limited treatment choices and dismal clinical outcomes. Using an integrative proteomics approach involving label-free phosphoproteome and proteome profiling, we delineated the downstream signaling pathways involved in SPINK1-mediated tumorigenesis and identified tyrosine kinase KIT as highly enriched. Furthermore, high to moderat ...[more]