Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Christine Mills
LAB HEAD: Joan Taylor
PROVIDER: PXD043212 | Pride | 2024-01-26
REPOSITORIES: Pride
Zhu Qiang Q Combs Matthew E ME Liu Juan J Bai Xue X Wang Wenbo B WB Herring Laura E LE Liu Jiandong J Locasale Jason W JW Bowles Dawn E DE Gross Ryan T RT Pla Michelle Mendiola MM Mack Christopher P CP Taylor Joan M JM
Nature communications 20231211 1
The serine/threonine kinase, PINK1, and the E3 ubiquitin ligase, Parkin, are known to facilitate LC3-dependent autophagosomal encasement and lysosomal clearance of dysfunctional mitochondria, and defects in this process contribute to a variety of cardiometabolic and neurological diseases. Although recent evidence indicates that dynamic actin remodeling plays an important role in PINK1/Parkin-mediated mitochondrial autophagy (mitophagy), the underlying signaling mechanisms remain unknown. Here, w ...[more]