Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
DISEASE(S): Parkinson's Disease
SUBMITTER: Alicia Flores
LAB HEAD: Dr Alino Martinez-Marcos
PROVIDER: PXD043503 | Pride | 2024-01-26
REPOSITORIES: Pride
Villar-Conde Sandra S Astillero-Lopez Veronica V Gonzalez-Rodriguez Melania M Saiz-Sanchez Daniel D Martinez-Marcos Alino A Ubeda-Banon Isabel I Flores-Cuadrado Alicia A
Molecular & cellular proteomics : MCP 20231029 12
α-Synuclein, a protein mostly present in presynaptic terminals, accumulates neuropathologically in Parkinson's disease in a 6-stage sequence and propagates in the nervous system in a prion-like manner through neurons and glia. In stage 3, the substantia nigra are affected, provoking motor symptoms and the amygdaloid complex, leading to different nonmotor symptoms; from here, synucleinopathy spreads to the temporal cortex and beyond. The expected increase in Parkinson's disease incidence accelera ...[more]