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Immunoprecipitation results against SmD2

ABSTRACT: We performed immunoprecipitation of SmD2 protein in the HCCLM3 cell line to seek proteins that interact with SmD2 in hepatocellular carcinoma.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Liver

SUBMITTER: Sun Linmao

LAB HEAD: Liu Lianxin

PROVIDER: PXD043535 | Pride | 2024-07-03

REPOSITORIES: Pride

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			Action	DRS
	F026937.dat	Other
	F026946.dat	Other
	R20211002056_IGG.raw	Raw
	R20211002056_PD2.raw	Raw
	checksum.txt	Txt

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Publications

Acetylation-dependent regulation of core spliceosome modulates hepatocellular carcinoma cassette exons and sensitivity to PARP inhibitors.

Sun Linmao L Liu Yufeng Y Guo Xinyu X Cui Tianming T Wu Chenghui C Tao Jie J Cheng Cheng C Chu Qi Q Ji Changyong C Li Xianying X Guo Hongrui H Liang Shuhang S Zhou Huanran H Zhou Shuo S Ma Kun K Zhang Ning N Wang Jiabei J Liu Yao Y Liu Lianxin L

Nature communications 20240618 1

Despite the importance of spliceosome core components in cellular processes, their roles in cancer development, including hepatocellular carcinoma (HCC), remain poorly understood. In this study, we uncover a critical role for SmD2, a core component of the spliceosome machinery, in modulating DNA damage in HCC through its impact on BRCA1/FANC cassette exons and expression. Our findings reveal that SmD2 depletion sensitizes HCC cells to PARP inhibitors, expanding the potential therapeutic targets. ...[more]

PMID: 38890388

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LILRA3-GFP and GFP only Transfected HEK293T cells LC-MSMS

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