Identifying the mechanism of platelet activation by platelet factor 4 (PF4) a.k.a CXCL4

ABSTRACT: We discovered that platelets become activated by platelet factor 4 and have looked into how this is the case. We used phosphoproteomics to identify proteins that were phosphorylated in a band on a Western blot at 95 kDa and identified phospho STAT5. We have subsequently shown that PF4 activates platelets through the JAK/STAT pathway.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Platelet

SUBMITTER: Richard Buka  

LAB HEAD: Phillip L R Nicolson

PROVIDER: PXD043558 | Pride | 2024-06-16

REPOSITORIES: Pride