Dataset Information

Pathogenesis of chikungunya virus infection associated with fatal outcome

ABSTRACT: Chikungunya virus (CHIKV) is a mosquito-borne virus that causes acute, subacute, and chronic human diseases and can cause neurological complications and death. Here, we combined epidemiological, virological, histopathological, cytokine, molecular dynamics, metabolomics, proteomics, and genomic analyses to investigate viral and pathophysiologic factors that contribute to deaths caused by chikungunya (CHIK). Our results indicate that CHIK-deaths presented multiple organs infection, central nervous system damage, and exhibited significantly elevated serum levels of pro-inflammatory cytokines and chemokines compared to survivors. The histopathology, metabolite, and proteomic signatures of CHIK-deaths revealed hemodynamic disorders and dysregulated immune system response. CHIKV East-Central-South-African lineage caused fatal and survivor cases, and CHIKV crosses the blood–brain barrier without tight junction alterations. IFN-λ3 was highly expressed in fatal cases but did not present a direct antiviral effect on CHIKV replication in vitro. In summary, our results reveal insights to improve understanding of CHIK pathogenesis, especially the pathophysiology of fatal infections.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Chikungunya

SUBMITTER: Victor Corasolla Carregari

LAB HEAD: Daniel Martins-de-Souza

PROVIDER: PXD043815 | Pride | 2024-06-16

REPOSITORIES: Pride

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			Action	DRS
	WilliamPlasma.DerivedFromSearch5597ee25-e141-4e7b-b5e5-2bb6a65fec43.mgf	Mgf
	WilliamPlasma.mzid.gz	Mzid
	WilliamRAWs.7z	Other
	checksum.txt	Txt

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Pathophysiology of chikungunya virus infection associated with fatal outcomes.

de Souza William M WM Fumagalli Marcilio J MJ de Lima Shirlene T S STS Parise Pierina L PL Carvalho Deyse C M DCM Hernandez Cristian C de Jesus Ronaldo R Delafiori Jeany J Candido Darlan S DS Carregari Victor C VC Muraro Stefanie P SP Souza Gabriela F GF Simões Mello Leda M LM Claro Ingra M IM Díaz Yamilka Y Kato Rodrigo B RB Trentin Lucas N LN Costa Clauber H S CHS Maximo Ana Carolina B M ACBM Cavalcante Karene F KF Fiuza Tayna S TS Viana Vânia A F VAF Melo Maria Elisabeth L MEL Ferraz Clarissa P M CPM Silva Débora B DB Duarte Larissa M F LMF Barbosa Priscilla P PP Amorim Mariene R MR Judice Carla C CC Toledo-Teixeira Daniel A DA Ramundo Mariana S MS Aguilar Patricia V PV Araújo Emerson L L ELL Costa Fabio T M FTM Cerqueira-Silva Thiago T Khouri Ricardo R Boaventura Viviane S VS Figueiredo Luiz Tadeu M LTM Fang Rong R Moreno Brechla B López-Vergès Sandra S Mello Liana Perdigão LP Skaf Munir S MS Catharino Rodrigo R RR Granja Fabiana F Martins-de-Souza Daniel D Plante Jessica A JA Plante Kenneth S KS Sabino Ester C EC Diamond Michael S MS Eugenin Eliseo E Proença-Módena José Luiz JL Faria Nuno R NR Weaver Scott C SC

Cell host & microbe 20240312 4

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes acute, subacute, and chronic human arthritogenic diseases and, in rare instances, can lead to neurological complications and death. Here, we combined epidemiological, virological, histopathological, cytokine, molecular dynamics, metabolomic, proteomic, and genomic analyses to investigate viral and host factors that contribute to chikungunya-associated (CHIK) death. Our results indicate that CHIK deaths are associated with multi ...[more]

PMID: 38479396

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